Figure 2
From: High-density SNP arrays improve detection of HER2 amplification and polyploidy in breast tumors
Co-amplification of chromosome 17 centromere andHER2. SNP data from tumor sample 26 displaying the copy number and allele ratios across chromosome 17. This sample has undergone multiple DNA breaks and several regions of the chromosome 17q arm are amplified, including a region around HER2 (4.46-fold) and a region close to the centromere. The two regions are amplified to the same extent and may therefore explain the negative IHC HER2/CEP17 even though the HER2 gene is clearly amplified.