Figure 3

Immunohistochemical localization of IKK-α, IkBα, and NFkB in serous papillary ovarian carcinoma. Immunoreactivity for IKK-α was weak in the OC group (A) and absent from the OC + Mel group (B). Moderate reaction for IKK-α was detected in the OC + EtOH (C) and OC + EtOH + Mel animals (D). Immunoreactivity for IkBα was moderate to high in the surface epithelium of the OC (E) and OC + EtOH groups (G) and was weak in the OC + Mel (F) and OC + EtOH + Mel groups (H). Strong immunoreactivity for NFkB was detected in the epithelium of the pappilae of the OC (I) and OC + EtOH groups (K). The OC + Mel (J) and OC + EtOH + Mel groups (L) displayed weak and moderate signals for NFkB, respectively (arrows; Bar = 20 μm).