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Figure 5 | BMC Cancer

Figure 5

From: Dermcidin exerts its oncogenic effects in breast cancer via modulation of ERBB signaling

Figure 5

Signaling pathways modulated by DCD. A, Expression of ERBB family of receptors and their ligands (B) in control and DCD shRNA-expressing cells. Y-axis indicates mean ± SD mRNA levels (normalized to HPRT) relative to pLKO controls. C, Proliferation-inducing activity of highly purified recombinant human DCD in MDA-MB-361 based on BrdU incorporation assay. Columns indicate mean of absorbance units, bars, SD. Real time PCR analyses of EGFR (D), C-myc (E), ERBB ligands (F) and ERBB receptors (G) at the indicated doses of rhDCD. Each sample was analyzed in three independent experiments performed in duplicates. * and ** denotes P < 0.05 and P <0.01, respectively, by Student’s t test. H, effects of EGF treatment on the phoshorylation of EGFR and downstream signaling proteins p38-MAPK and pAkt in MDA-MB-361 control and DCD shRNA-expressing following of treatment with EGF 10 ng/ml for 15 minutes.

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