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Table 1 EGFR and MET gene status of 35 lung adenocarcinoma cases

From: MET FISH-positive status predicts short progression-free survival and overall survival after gefitinib treatment in lung adenocarcinoma with EGFR mutation

       Before Gefitinib treatments   At Gefitinib treatment failure
Case No b Smoking Staging Gefitinib response EGFR mutation type MET FISH status MET IHC EGFR mutation type MET FISH status PFS(Months) OS(Months)
1 - IV PR Ex19 deletion ++ + Ex19 deletion ++ 7.3 15
2 - IV PR Ex19 deletion +   Not detected + 7.6 11.9
3 + Relapse PR Ex19 deletion +   Ex19 deletion/T790M + 18.5 34.4
4 - Relapse PR Ex19 deletion + -    16.6 20.9
5 + IIIA PR Ex19 deletion +     8.5 20
6 - Relapse PR Ex19 deletion +     1.8 1.8
7 - IV PD L858R +   L858R + 13.6 15
8 + Relapse PD L858R + +    2.7 8.8
9 - Relapse CR L858R + -    13 28.4
10 - Relapse PR L858R + -    7.6 11.2
11 + IV PR L858R +     5.7 7.3
12 + IV PR Ex19 deletion -   Ex19 deletion - 13.9 21
13 + IV PR Ex19 deletion -   Ex19 deletion - 10.4 36.4
14 - IV PR Ex19 deletion -   Ex19 deletion - 24.7 31.1
15 - Relapse PR Ex19 deletion - - Ex19 deletion/T790M - 28.4 33.8
16 - Relapse PR Ex19 deletion - -    11.1 21
17 + Relapse PR Ex19 deletion - -    24.4 24.4
18 - IIIA PR Ex19 deletion -     6.5 14.9
19 - IIIB PR Ex19 deletion -     29.8 38.2
20 + IIIB PR Ex19 deletion -     41.5 48.6
21 - IV PR Ex19 deletion -     13.2 26.7
22 + IV PR Ex19 deletion -     17.1 17.1
23 - IV PR Ex19 deletion -     13.3 19.2
24 - IV PR Ex19 deletion -     21.8 25.5
25 - IV PR Ex19 deletion -     15.2 31.6
26 - IV SD Ex19 deletion -     3.4 26.8
27 + Relapse PR Ex19 deletion -     18.7 50.2
28 + Relapse PR Ex19 deletion -     15.9 20.2
29 - Relapse PR Ex19 deletion -     12.1 15
30 + Relapse SD Ex19 deletion -     11.1 13.6
31 - Relapse PR L858R -   L858R - 58.7 123.5
32 - IV PR L858R - -    4.5 4.5
33 + Relapse PR L858R -     15.5 16.7
34 + Relapse PR L858R -     13.5 13.5
35 - Relapse PR L858R -     7.1 7.1
  1. MET FISH status; ++Amplification, +High polysomy.
  2. bPatient identifiers have been removed and relabeled.