Table 1 Mutation frequency of genes for which hotspot regions are present in the gene-panel
Gene | Chr | RefSeq | Function | % Mutated CRC# | % Mutated lung cancer# |
|---|---|---|---|---|---|
AKT1 | 14 | NM_005163.2 | Oncogene | 0.64 | 0.42 |
ALK | 2 | NM_004304.3 | Oncogene | 2.74 | 5.25 |
BRAF | 7 | NM_004333.4 | Oncogene | 12.19 | 2.46 |
CTNNB1 | 3 | NM_001904.3 | Oncogene | 4.61 | 3.13 |
DDR2 | 1 | NM_006182.2 | Oncogene | 0 | 0.21 |
EGFR | 7 | NM_005228.3 | Oncogene | 2.75 | 26.71 |
ERBB2 | 17 | NM_004448.2 | Oncogene | 1.48 | 1.80 |
ERBB4 | 2 | NM_005235.2 | Oncogene | 3.84 | 8.35 |
FGFR1 | 8 | NM_023110.2 | Oncogene | 0.55 | 1.62 |
FGFR2 | 10 | NM_000141.4 | Oncogene | 0.42 | 1.68 |
FGFR3 | 4 | NM_000142.4 | Oncogene | 0.53 | 0.92 |
KRAS | 12 | NM_004985.3 | Oncogene | 34.51 | 16.23 |
MAP2K1 | 15 | NM_002755.3 | Oncogene | 0.15 | 1.14 |
MET | 7 | NM_001127500.1 | Oncogene | 0.73 | 3.03 |
NOTCH1 | 9 | NM_017617.3 | Oncogene | 0.13 | 3.44 |
NRAS | 1 | NM_002524.3 | Oncogene | 3.37 | 0.88 |
PIK3CA | 3 | NM_006218.2 | Oncogene | 11.90 | 4.08 |
FBXW7 | 4 | NM_0033632.2 | Tumor suppressor | 6.83 | 3.00 |
PTEN | 10 | NM_000314.4 | Tumor suppressor | 3.86 | 3.59 |
SMAD4 | 18 | NM_005359.5 | Tumor suppressor | 7.89 | 2.68 |
STK11 | 19 | NM_000455.4 | Tumor suppressor | 1.28 | 8.40 |
TP53 | 17 | NM_000546.5 | Tumor suppressor | 41.75 | 37.64 |