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Table 3 ES-SBA - relapse free survival by prognostic factors

From: Prognostic factors and treatment outcomes in patients with Small Bowel Adenocarcinoma (SBA): The Royal Marsden Hospital (RMH) experience

 

Number events/Number subjects

5 Year survival (95% CI)

Hazard ratio (95% CI)

p-value

Gender

Male

16/24

23.1 (3.7 – 42.5)

1.58 (0.74 – 3.36)

0.236

 

Female

12/20

45.0 (23.2 – 66.8)

-

 

Primary tumour

13/27

54.3 (34.3 – 74.3)

-

(p = 0.019)

 

Duodenum

8/9

11.1 (0 – 31.7)

1.91 (0.78 – 4.65)

0.154

 

Jejunum

6/7

0

3.54 (1.28 – 9.7)

0.014

 

Ileum

1/1

0

 

0.016

Small bowel unknown

  

15.9 (1.69 – 150)

 

Grade (differentiation)

Low/Moderate

13/27

47.2 (26.4 – 68.0)

-

 
 

Poor

14/16

15.0 (0 – 33.6)

3.16 (1.43 – 6.97)

0.004

Nodes harvested

<12

15/20

50.3 (30.3 – 70.3)

-

 
 

≥12

4/14

74.1 (48.8 – 99.4)

0.41 (0.14 – 1.24)

0.113

Nodes involved

Negative (Stage I/II)

15/30

40.8 (21.2 – 60.4)

-

 
  

8/9

 

1.90 (0.80 - 4.51)

0.144

 

Positive (Stage III)

 

33.3 (2.5 – 64.1)

  

LVI

No

7/18

55.1 (27.9 – 82.3)

-

 
 

Yes

15/19

25.3 (5.3 – 45.3)

3.18 (1.28 – 7.89)

0.013

PNI

No

14/27

38.7 (18.3 – 59.1)

-

 
 

Yes

8/10

40.0 (9.6 – 70.4)

1.27 (0.53 – 3.06)

0.589

Adjuvant Chemo

No

11/20

42.3 (18.8 – 65.8)

-

 
 

Yes

17/24

28.1 (8.9 – 47.3)

1.26 (0.58 – 2.74)

0.555

Small Bowel Obstruction

None

14/25

42.8 (22.2 – 63.4)

-

 
 

Present

6/8

0

1.95 (0.74 – 5.15)

0.180

Weight loss

None

16/27

36.1 (16.3 – 55.9)

-

 
 

Present

4/6

33.3 (0 – 70.9)

1.45 (0.48 – 4.36)

0.505

CEA at baseline

Normal

8/19

53.8 (29.5 – 78.1)

-

 
 

Abnormal

13/15

26.7 (4.4 – 49.0)

2.25 (0.93 – 5.46)

0.074

Haemoglobin

Normal

9/14

36.4 (9.0 – 63.8)

-

 
 

Abnormal

14/20

35.0 (14.0 – 56.0)

1.13 (0.49 – 2.61)

0.781

Albumin

Normal

12/19

38.5 (15.6 – 61.4)

-

 
 

Abnormal

11/15

33.3 (9.4 – 57.2)

1.09 (0.48 – 2.48)

0.838

LDH

Normal

8/12

33.3 (3.7 – 62.9)

-

 
 

Abnormal

7/11

36.4 (8.0 – 64.8)

0.88 (0.32 – 2.45)

0.808

Alk.Ph

Normal

13/21

39.8 (18.0 – 61.6)

-

 
 

Abnormal

10/13

30.8 (5.7 – 55.9)

1.08 (0.47 – 2.47)

0.858

ALT

Normal

16/26

40.0 (20.6 – 59.4)

-

 
 

Abnormal

6/7

28.6 (0 – 62.1)

1.23 (0.48 – 3.18)

0.671

Platelets

Normal

24/40

38.0 (21.7 – 54.3)

-

 
 

Abnormal

1/1

0

4.15 (0.52 – 33.2)

0.180

  1. Where the normal values are:
  2. CEA: ≤ 3.
  3. Platelets: 150 – 400 × 109/l.
  4. Hemoglobin: Male: 13.0 – 17.0 mg/l .
  5. Female: 12.0 - 15.0 mg/l.
  6. Albumin: >35 g/l.
  7. LDH: 98–192 U/l.
  8. ALP: 24–110 U/l.
  9. ALT: <40 U/l.