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Table 3 ES-SBA - relapse free survival by prognostic factors

From: Prognostic factors and treatment outcomes in patients with Small Bowel Adenocarcinoma (SBA): The Royal Marsden Hospital (RMH) experience

  Number events/Number subjects 5 Year survival (95% CI) Hazard ratio (95% CI) p-value
Gender Male 16/24 23.1 (3.7 – 42.5) 1.58 (0.74 – 3.36) 0.236
  Female 12/20 45.0 (23.2 – 66.8) -  
Primary tumour 13/27 54.3 (34.3 – 74.3) - (p = 0.019)
  Duodenum 8/9 11.1 (0 – 31.7) 1.91 (0.78 – 4.65) 0.154
  Jejunum 6/7 0 3.54 (1.28 – 9.7) 0.014
  Ileum 1/1 0   0.016
Small bowel unknown    15.9 (1.69 – 150)  
Grade (differentiation) Low/Moderate 13/27 47.2 (26.4 – 68.0) -  
  Poor 14/16 15.0 (0 – 33.6) 3.16 (1.43 – 6.97) 0.004
Nodes harvested <12 15/20 50.3 (30.3 – 70.3) -  
  ≥12 4/14 74.1 (48.8 – 99.4) 0.41 (0.14 – 1.24) 0.113
Nodes involved Negative (Stage I/II) 15/30 40.8 (21.2 – 60.4) -  
   8/9   1.90 (0.80 - 4.51) 0.144
  Positive (Stage III)   33.3 (2.5 – 64.1)   
LVI No 7/18 55.1 (27.9 – 82.3) -  
  Yes 15/19 25.3 (5.3 – 45.3) 3.18 (1.28 – 7.89) 0.013
PNI No 14/27 38.7 (18.3 – 59.1) -  
  Yes 8/10 40.0 (9.6 – 70.4) 1.27 (0.53 – 3.06) 0.589
Adjuvant Chemo No 11/20 42.3 (18.8 – 65.8) -  
  Yes 17/24 28.1 (8.9 – 47.3) 1.26 (0.58 – 2.74) 0.555
Small Bowel Obstruction None 14/25 42.8 (22.2 – 63.4) -  
  Present 6/8 0 1.95 (0.74 – 5.15) 0.180
Weight loss None 16/27 36.1 (16.3 – 55.9) -  
  Present 4/6 33.3 (0 – 70.9) 1.45 (0.48 – 4.36) 0.505
CEA at baseline Normal 8/19 53.8 (29.5 – 78.1) -  
  Abnormal 13/15 26.7 (4.4 – 49.0) 2.25 (0.93 – 5.46) 0.074
Haemoglobin Normal 9/14 36.4 (9.0 – 63.8) -  
  Abnormal 14/20 35.0 (14.0 – 56.0) 1.13 (0.49 – 2.61) 0.781
Albumin Normal 12/19 38.5 (15.6 – 61.4) -  
  Abnormal 11/15 33.3 (9.4 – 57.2) 1.09 (0.48 – 2.48) 0.838
LDH Normal 8/12 33.3 (3.7 – 62.9) -  
  Abnormal 7/11 36.4 (8.0 – 64.8) 0.88 (0.32 – 2.45) 0.808
Alk.Ph Normal 13/21 39.8 (18.0 – 61.6) -  
  Abnormal 10/13 30.8 (5.7 – 55.9) 1.08 (0.47 – 2.47) 0.858
ALT Normal 16/26 40.0 (20.6 – 59.4) -  
  Abnormal 6/7 28.6 (0 – 62.1) 1.23 (0.48 – 3.18) 0.671
Platelets Normal 24/40 38.0 (21.7 – 54.3) -  
  Abnormal 1/1 0 4.15 (0.52 – 33.2) 0.180
  1. Where the normal values are:
  2. CEA: ≤ 3.
  3. Platelets: 150 – 400 × 109/l.
  4. Hemoglobin: Male: 13.0 – 17.0 mg/l .
  5. Female: 12.0 - 15.0 mg/l.
  6. Albumin: >35 g/l.
  7. LDH: 98–192 U/l.
  8. ALP: 24–110 U/l.
  9. ALT: <40 U/l.