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Table 4 Multivariate logistic regression analysis showing associations of relevant histopathological features in non-metastatic (N0/M0) versus lymphogenous-metastatic (N+) and haematogenous-metastatic (M+) CC

From: Histopathological features predict metastatic potential in locally advanced colon carcinomas

  N0/M0 vs. N+ N0/M0 vs. M+
  OR (95% CI) p-value OR (95% CI) p-value
Tumor budding low vs. high 5.99 (1.28-27.90) 0.023 8.70 (1.83-41.42) 0.007
Inflammation zone 1 lymphocytic vs.non-lymphocytic 0.06 (0.01-0.52) 0.012 0.20 (0.03-1.38) NS
Tumor/Necrosis ratio (> median, ≤median)    0.46 (0.13-1.62) NS
Tumor/Desmoplasia ratio (> median, ≤median) 0.17 (0.04-0.73) 0.017   
Desmoplastic pattern finger-like vs. non-finger-like 0.18 (0.03-0.89) 0.037   
Large vessel density zone 3 (> median, ≤median) 2.437 (0.61-9.69) NS   
Small vessel density zone 1 (> median, ≤median)    0.33 (0.09-1.23) NS
  1. OR: odds ratio, CI: confidence interval, NS: no significant.