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Table 3 PRDM5 methylation and expression and other molecular features of serrated and conventional polyp subgroups

From: Methylation and expression of the tumour suppressor, PRDM5, in colorectal cancer and polyp subgroups

  Serrated Polyps Conventional Adenomas P value
  MVHP SSA TSA TVA TA Serrated vs conventional
N 19 20 20 20 20 -
PRDM5 Methylation 2 (11%) 2 (10%) 2 (10%) 0 0 0.08
PRDM5 Average 3.4 2.2 3.6 1.1 0.4 0.01
PMR score
PRDM5 IHC 5 (26%) 12 (60%) 12 (60%) 12 (60%) 11 (55%) 0.5
Negative Expression
BRAF mutation 18 (95%) 17 (85%) 13 (65%) 0 0 <0.0001
KRAS mutation 0 1 (5%) 4 (20%) 3 (15%) 1 (5%) 1.0
CIMP High 2 (11%) 12 (60%) 9 (45%) 0 0 <0.0001
Nuclear Beta-Catenin 0 0 3 (15%) 17 (85%) 9 (45%) <0.0001
  1. Significant p values indicated in bold text.