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Table 1 Summary of mutated genes in endometrial cancer (Em Ca) and peritoneal malignant mesothelioma (PMM) measured using massively parallel sequencing (MiSeq) and molecular inversion probe microarray (OncoScan)

From: Molecular characteristics of endometrial cancer coexisting with peritoneal malignant mesothelioma in Li-Fraumeni-like syndrome

     Em Ca (35%) PMM (70%)
Gene Code Amino acid change Chromosome MiSeq sequencing# OncoScan MIP microarrayξ MiSeq sequencing# OncoScan MIP microarrayξ
TP53* 215G > C Pro/Arg 17 + (55%) NA + (33%) NA
PIK3CA 1624G > A Glu/Lys 3 + (34%) + - -
GNA11 973 T > C Tyr/His 19 - NA + (32%) NA
JAK3 703C > T Ser/Asn 19 - NA + (44%) NA
  1. Abbreviation:MIP molecular inversion probe.
  2. *This mutation is also found in patient’s blood.
  3. Numbers in the brackets indicate the percentage of tumor cells observed by the pathologist.
  4. #Numbers indicate the percentage of alternate alleles.
  5. ξAnalyzed by “somatic mutation viewer” (Additional file 3), NA: data not available.