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Table 1 Summary of mutated genes in endometrial cancer (Em Ca) and peritoneal malignant mesothelioma (PMM) measured using massively parallel sequencing (MiSeq) and molecular inversion probe microarray (OncoScan)

From: Molecular characteristics of endometrial cancer coexisting with peritoneal malignant mesothelioma in Li-Fraumeni-like syndrome

    

Em Ca (35%)‡

PMM (70%)‡

Gene

Code

Amino acid change

Chromosome

MiSeq sequencing#

OncoScan MIP microarrayξ

MiSeq sequencing#

OncoScan MIP microarrayξ

TP53*

215G > C

Pro/Arg

17

+ (55%)

NA

+ (33%)

NA

PIK3CA

1624G > A

Glu/Lys

3

+ (34%)

+

-

-

GNA11

973 T > C

Tyr/His

19

-

NA

+ (32%)

NA

JAK3

703C > T

Ser/Asn

19

-

NA

+ (44%)

NA

  1. Abbreviation:MIP molecular inversion probe.
  2. *This mutation is also found in patient’s blood.
  3. ‡Numbers in the brackets indicate the percentage of tumor cells observed by the pathologist.
  4. #Numbers indicate the percentage of alternate alleles.
  5. ξAnalyzed by “somatic mutation viewer” (Additional file 3), NA: data not available.
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BMC Cancer

ISSN: 1471-2407

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