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Figure 4 | BMC Cancer

Figure 4

From: Clinical observations on chemotherapy curable malignancies: unique genetic events, frozen development and enduring apoptotic potential

Figure 4

Spermatogenesis and cancer development. The normal and malignant development of testicular germ cells. The normal progression from the primordial germ cell to the production of sperm is shown in the upper pathway. Testicular germ cell tumours develop via CIS from arrested gonocytes that have an impaired mitosis/meiosis switch. Spermatocytic seminoma the malignancy arising from normal pre-meiotic spermatogonia is characteristically chemotherapy resistant.

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BMC Cancer

ISSN: 1471-2407

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