The novel histone deacetylase inhibitor, N-hydroxy-7-(2-naphthylthio) hepatonomide, exhibits potent antitumor activity due to cytochrome-c-release-mediated apoptosis in renal cell carcinoma cells

Table 1 IC ₅₀ (half maximal inhibitory concentration) determination using a cell proliferation assay

Cell line	Tissue derived	Animal	Cell proliferation IC50 (μM)
			HNHA	TSA	SAHA
Caki-1	Kidney: clear cell type renal cell arcinoma	Human	20.61 (±0.9)	49.29 (±1.1)	32.14 (±1.1)
A498	Kidney; renal cell carcinoma	Human	20.95 (±1.0)	40.19 (±1.4)	33.01 (±1.8)
786-O	Kidney; clear cell type renal cell carcinoma	Human	23.29 (±1.1)	45. 30 (±1.0)	30.97 (±1.7)
UMRC-3	Kidney; clear cell type renal cell carcinoma	Human	32.28 (±1.0)	53.42 (±1.0)	40.13 (±0.7)

Each data point represents the mean of three independent IC₅₀ experiments performed in triplicate by MTT assay. SD, standard deviation.

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