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Table 1 IC 50 (half maximal inhibitory concentration) determination using a cell proliferation assay

From: The novel histone deacetylase inhibitor, N-hydroxy-7-(2-naphthylthio) hepatonomide, exhibits potent antitumor activity due to cytochrome-c-release-mediated apoptosis in renal cell carcinoma cells

Cell line Tissue derived Animal Cell proliferation IC50 (μM)
    HNHA TSA SAHA
Caki-1 Kidney: clear cell type renal cell arcinoma Human 20.61 (±0.9) 49.29 (±1.1) 32.14 (±1.1)
A498 Kidney; renal cell carcinoma Human 20.95 (±1.0) 40.19 (±1.4) 33.01 (±1.8)
786-O Kidney; clear cell type renal cell carcinoma Human 23.29 (±1.1) 45. 30 (±1.0) 30.97 (±1.7)
UMRC-3 Kidney; clear cell type renal cell carcinoma Human 32.28 (±1.0) 53.42 (±1.0) 40.13 (±0.7)
  1. Each data point represents the mean of three independent IC50 experiments performed in triplicate by MTT assay. SD, standard deviation.