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Figure 4 | BMC Cancer

Figure 4

From: The novel histone deacetylase inhibitor, N-hydroxy-7-(2-naphthylthio) hepatonomide, exhibits potent antitumor activity due to cytochrome-c-release-mediated apoptosis in renal cell carcinoma cells

Figure 4

HNHA induced caspase-dependent apoptotic death of RCC cells. Immunoblot analysis for Bcl-2, phospho-IκB, and caspases-3 and -7 in Caki-1 and A-498 cells (A, B). TUNEL assay of apoptotic cells in Caki-1 and A-498 cells; TUNEL-positive (apoptotic) cells are indicated (×400) (C).

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