Figure 4From: The novel histone deacetylase inhibitor, N-hydroxy-7-(2-naphthylthio) hepatonomide, exhibits potent antitumor activity due to cytochrome-c-release-mediated apoptosis in renal cell carcinoma cellsHNHA induced caspase-dependent apoptotic death of RCC cells. Immunoblot analysis for Bcl-2, phospho-IκB, and caspases-3 and -7 in Caki-1 and A-498 cells (A, B). TUNEL assay of apoptotic cells in Caki-1 and A-498 cells; TUNEL-positive (apoptotic) cells are indicated (×400) (C).Back to article page