Staged stromal extracellular 3D matrices differentially regulate breast cancer cell responses through PI3K and beta1-integrins

Table 6 directionality P values

Sample	2D	3D Ctrl	Wt 10 nM	Wt 50 nM	mAb13	mAb13 + Wt 10 nM	mAb13 Wt 50 nM
untreated
Ctrl	< 0.0014**	-	0.0219*	< 0.0001***	0.2395	0.6252	0.0377*
TA	< 0.0001***	0.0109*	0.6641	0.5551	< 0.0001***	< 0.0001***	< 0.0001***
Wt 10 nM
Ctrl	-	-	-	0.3691	0.0545	0.0109*	0.1144
TA	-	-	-	0.3983	< 0.0001***	< 0.0001***	< 0.0001***
Wt 50 nM
Ctrl	-	-	-	-	0.0002***	< 0.0001***	0.0004***
TA	-	-	-	-	< 0.0001***	< 0.0001***	< 0.0001***
mAb13
Ctrl	-	-	-	-	-	0.2808	0.5132
TA	-	-	-	-	-	0.4318	0.2500
mAb13 + Wt 10 nM
Ctrl	-	-	-	-	-	-	0.0568
TA	-	-	-	-	-	-	0.8769

P values were obtained using Mann-Whitney test. Non-significant values are underlined while relative significance levels are designated as extremely***, very**, or significant*. Bolded data represent conditions in which differences were observed between control and tumor-associated 3D matrix induced directionality due to stated treatments.

ISSN: 1471-2407