Figure 5

DDP resistance of p75 ^NTR+ cells. Treated with 0.5 and 1 μg/ml DDP for 4 days, the number of viable cells in p75^NTR+subpopulation was significant higher than that in p75^NTR- subpopulation. (B) Enrichment assay showed that the fraction of eGFP-carrying cells derived from p75^NTR+ cells increased from 9.4% to 48.1% and 86.2%, respectively. (C) Copper accumulation was less in the p75^NTR+ cells than in the p75^NTR- cells at each time point. (B, bars = 100 μm)