Figure 1From: Self-renewal and chemotherapy resistance of p75NTR positive cells in esophageal squamous cell carcinomas Parallel sections from normal esophageal epithelial and ESCC specimen. (A) In NEE, p75NTR was located mainly in the basal layer; in WDC, p75NTR positive staining was apparent in the first one to two layers from the infiltrative margin, areas exhibiting stratified squamous pearl formation were negative for p75NTR; in MDC, p75NTR was expressed in wider range from the margin of the tumors; p75NTR was diffusely distributed in PDC.(B) In NEE, basal cells coexpressed p75NTR and p63, and very few p75NTR+ cells expressed ki-67; in WDC and MDC, p75NTR+ cells were at some distance surrounding involucrin+cells where most of the cells were coexpressed p63, and a small proportion of p75NTR+ cells expressed ki-67; in PDC, few cells were positive for involucrin, more cells contained both p63 and p75NTR, and their distribution was chaotic, a large number of p75NTR+ cells stained brightly for ki-67. (Bars = 200 μm)Back to article page