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Table 4 Clinico-pathological characteristics and tumor levels

From: Circulating cell death products predict clinical outcome of colorectal cancer patients

Patient and tumor characteristics No of patients (%) Total n = 40 CK18-Asp396 level (U/mg) Median (IQR) P-value Total CK18 level (U/mg) Median (IQR) P-value CK18-Asp396/CK18 × 100 Median (IQR) P-value
Gender    0.94   0.67   0.96
   Male 26 2.1 (0.2–7.7)   203.0 (64.0–318.2)   1.9 (0.3–3.7)  
   Female 14 1.3 (0.2–10.3)   159.0 (33.2–273.5)   1.7 (0.2–3.6)  
Age (median 68 year)    0.98   0.29   0.77
   ≤ median 20 1.4 (0.3–6.1)   165.0 (53.0–331.7)   1.8 (0.5–3.4)  
   > median 20 2.2 (0.2–9.7)   219.1 (57.0–248.9)   2.2 (0.2–3.8)  
Location    0.003   0.03   0.005
   Colon 32 0.8 (0.2–5.7)   147.0 (47.1–243.3)   1.4 (0.2–2.4)  
   Rectum 8 12.7 (3.5–19.5)   291.5 (214.6–369.7)   3.7 (2.8–6.3)  
Dukes' stage    0.79   0.49   0.90
   A/B 25 1.6 (0.3–9.7)   177.1 (71.8–310.2)   1.8 (0.2–3.4)  
   C/D 15 1.3 (0.1–5.9)   222.4 (32.7–252.1)   2.0 (0.4–3.8)  
WHO classification    0.90   0.49   0.94
   Adenocarcinoom 37 1.6 (0.3–7.7)   190.3 (56.9–281.9)   1.9 (0.3–3.4)  
   Mucinous carcinoom 3 1.1   65.4   1.7  
Tumor diameter (median 4.5 cm)*    0.37   0.43   0.31
   ≤ median 20 4.3 (0.3–10.3)   203.0 (56.9–310.2)   2.3 (0.3–3.9)  
   > median 18 1.3 (0.1–5.7)   154.0 (36.7–281.9)   1.6 (0.2–2.3)  
  1. Clinico-pathological characteristics and tumor CK18-Asp396, total CK18 and CK18-Asp396/CK18 ratios. P-values were calculated with Kruskall-Wallis and Mann-Whitney tests and P ≤ 0.05 were considered significant, shown in bold. * Some values missing.