Table 3 Univariate and multivariate Cox regression analysis
From: Circulating cell death products predict clinical outcome of colorectal cancer patients
Patient and tumor characteristics | Univariate Hazard Ratio (95% confidence interval) | P-value | Multivariate Hazard Ratio (95% confidence interval) | P-value |
|---|---|---|---|---|
Gender | 0.27 | |||
Female | 1 (ref) | |||
Male | 1.79 (0.64–497) | |||
Age (median 68 year) | 0.83 | |||
≤ median | 1 (ref) | |||
> median | 1.10 (0.45–2.73) | |||
Location | 0.32 | |||
Colon | 1 (ref) | |||
Rectum | 0.54 (0.16–1.85) | |||
Dukes' stage | <0.001 | <0.001–0.021 | ||
A/B | 1 (ref) | 1(ref) | ||
C/D | 8.21 (2.70–24.97) | 6.01–9.60 (1.32–33.31) | ||
Tumor diameter (median 4.5 cm) | 0.32 | |||
≤ median | 1 (ref) | |||
> median | 1.68 (0.61–4.65) | |||
WHO classification | 0.82 | |||
Adenocarcinoom | 1 (ref) | |||
Mucinous carcinoom | 0.79 (0.11–5.90) | |||
CK18-Asp396 plasma level P1 | 0.003 | 0.03 | ||
≤ median | 1 (ref) | 1 (ref) | ||
> median | 5.28 (1.75–15.92) | 3.58 (1.17–11.02) | ||
Total CK18 plasma level P1 | 0.02 | 0.055 | ||
≤ median | 1 (ref) | 1 (ref) | ||
> median | 3.30 (1.19–9.16) | 3.58 (0.97–7.71) | ||
CK18-Asp396/CK18 ratio P1 | 0.12 | 0.04 | ||
≤ median | 2.09 (0.82–5.31) | 2.78 (1.06–7.19) | ||
> median | 1 (ref) | 1 (ref) | ||
CK18-Asp396 plasma level P3 | 0.054 | 0.10 | ||
≤ median | 1 (ref) | 1 (ref) | ||
> median | 4.71 (0.97–22.85) | 3.78 (0.77–18.50) | ||
Total CK18 plasma level P3 | 0.055 | 0.08 | ||
≤ median | 1 (ref) | 1 (ref) | ||
> median | 4.69 (0.97–22.72) | 4.12 (0.84–20.34) | ||
CK18-Asp396/CK18 ratio P3 | 0.04 | 0.10 | ||
≤ median | 5.28 (1.08–25.72) | 3.96 (0.78–20.08) | ||
> median | 1 (ref) | 1 (ref) |