Skip to main content

Table 3 Univariate and multivariate Cox regression analysis

From: Circulating cell death products predict clinical outcome of colorectal cancer patients

Patient and tumor characteristics Univariate Hazard Ratio (95% confidence interval) P-value Multivariate Hazard Ratio (95% confidence interval) P-value
Gender   0.27   
   Female 1 (ref)    
   Male 1.79 (0.64–497)    
Age (median 68 year)   0.83   
   ≤ median 1 (ref)    
   > median 1.10 (0.45–2.73)    
Location   0.32   
   Colon 1 (ref)    
   Rectum 0.54 (0.16–1.85)    
Dukes' stage   <0.001   <0.001–0.021
   A/B 1 (ref)   1(ref)  
   C/D 8.21 (2.70–24.97)   6.01–9.60 (1.32–33.31)  
Tumor diameter (median 4.5 cm)   0.32   
   ≤ median 1 (ref)    
   > median 1.68 (0.61–4.65)    
WHO classification   0.82   
   Adenocarcinoom 1 (ref)    
   Mucinous carcinoom 0.79 (0.11–5.90)    
CK18-Asp396 plasma level P1   0.003   0.03
   ≤ median 1 (ref)   1 (ref)  
   > median 5.28 (1.75–15.92)   3.58 (1.17–11.02)  
Total CK18 plasma level P1   0.02   0.055
   ≤ median 1 (ref)   1 (ref)  
   > median 3.30 (1.19–9.16)   3.58 (0.97–7.71)  
CK18-Asp396/CK18 ratio P1   0.12   0.04
   ≤ median 2.09 (0.82–5.31)   2.78 (1.06–7.19)  
   > median 1 (ref)   1 (ref)  
CK18-Asp396 plasma level P3   0.054   0.10
   ≤ median 1 (ref)   1 (ref)  
   > median 4.71 (0.97–22.85)   3.78 (0.77–18.50)  
Total CK18 plasma level P3   0.055   0.08
   ≤ median 1 (ref)   1 (ref)  
   > median 4.69 (0.97–22.72)   4.12 (0.84–20.34)  
CK18-Asp396/CK18 ratio P3   0.04   0.10
   ≤ median 5.28 (1.08–25.72)   3.96 (0.78–20.08)  
   > median 1 (ref)   1 (ref)  
  1. Cox hazards analysis of patient and tumor characteristics in relation to disease-free survival. Multivariate Cox hazards analysis of pre-operative or post-operative CK18-Asp396, total CK18 antigen level or CK18-Asp396/CK18 ratios combined with Dukes' stage. P ≤ 0.05 were considered significant, shown in bold.