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Table 2 Clinico-pathological characteristics and pre-operative plasma levels

From: Circulating cell death products predict clinical outcome of colorectal cancer patients

Patient and tumor characteristics No of patients (%)
Total n = 49
Plasma CK18-Asp396 (U/l) Median (IQR) P-value Total CK18 plasma level (U/l) Median (IQR) P-value
Gender    0.87   0.92
   Male 31 (63) 61.1 (41.8–88.2)   260.5 (174.1–382.8)  
   Female 18 (37) 50.5 (37.6–110.2)   252.9 (184.5–352.1)  
Age (median 68 year, range 31–84)    0.32   0.38
   ≤ median 25 (51) 59.1 (15.1–99.0)   288.6 (181.6–403.5)  
   > median 24 (49) 55.6 (34.2–74.0)   232.4 (177.3–328.6)  
Location    0.63   0.25
   Colon 38 (78) 59.4 (40.5–102.8)   268.6 (199.7–391.1)  
   Rectum 11 (22) 56.4 (43.3–68.4)   208.4 (174.1–377.9)  
Dukes' stage    0.01   0.05
   A/B 27 (55) 49.3 (34.2–67.8)   235.0 (170.5–303.5)  
   C/D 22 (45) 69.2 (49.7–114.5)   295.8 (202.3–706.3)  
WHO classification    0.43   0.56
   Adenocarcinoom 45 (92) 59.1 (39.9–82.2)   265.4 (186.7–378.3)  
   Mucinous carcinoom 4 (8) 77.8 (48.9–177.7)   211.2 (172.0–363.1)  
Tumor diameter (median 4.5 cm, range 2–13.5)*    0.03   0.07
   ≤ median 24 (55) 49.1 (31.9–67.7)   232.4 (174.5–187.7)  
   > median 20 (45) 64.7 (43.7–133.3)   287.3 (180.0–657.6)  
Surgery    0.001   <0.001
   Yes, curative resection 41 (84) 51.1 (36.5–73.7)   235.0 (172.3–331.9)  
   No, or palliative 8 (16) 162.9 (68.8–346.4)   971.7 (306.1–2290.4)  
  1. Clinico-pathological characteristics and pre-operative CK18-Asp396 and total CK18 plasma levels. P-values were calculated with Kruskal-Wallis and Mann-Whitney tests and P ≤ 0.05 were considered significant, shown in bold. * Some values missing.