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Table 2 Clinico-pathological characteristics and pre-operative plasma levels

From: Circulating cell death products predict clinical outcome of colorectal cancer patients

Patient and tumor characteristics

No of patients (%)

Total n = 49

Plasma CK18-Asp396 (U/l) Median (IQR)

P-value

Total CK18 plasma level (U/l) Median (IQR)

P-value

Gender

  

0.87

 

0.92

   Male

31 (63)

61.1 (41.8–88.2)

 

260.5 (174.1–382.8)

 

   Female

18 (37)

50.5 (37.6–110.2)

 

252.9 (184.5–352.1)

 

Age (median 68 year, range 31–84)

  

0.32

 

0.38

   ≤ median

25 (51)

59.1 (15.1–99.0)

 

288.6 (181.6–403.5)

 

   > median

24 (49)

55.6 (34.2–74.0)

 

232.4 (177.3–328.6)

 

Location

  

0.63

 

0.25

   Colon

38 (78)

59.4 (40.5–102.8)

 

268.6 (199.7–391.1)

 

   Rectum

11 (22)

56.4 (43.3–68.4)

 

208.4 (174.1–377.9)

 

Dukes' stage

  

0.01

 

0.05

   A/B

27 (55)

49.3 (34.2–67.8)

 

235.0 (170.5–303.5)

 

   C/D

22 (45)

69.2 (49.7–114.5)

 

295.8 (202.3–706.3)

 

WHO classification

  

0.43

 

0.56

   Adenocarcinoom

45 (92)

59.1 (39.9–82.2)

 

265.4 (186.7–378.3)

 

   Mucinous carcinoom

4 (8)

77.8 (48.9–177.7)

 

211.2 (172.0–363.1)

 

Tumor diameter (median 4.5 cm, range 2–13.5)*

  

0.03

 

0.07

   ≤ median

24 (55)

49.1 (31.9–67.7)

 

232.4 (174.5–187.7)

 

   > median

20 (45)

64.7 (43.7–133.3)

 

287.3 (180.0–657.6)

 

Surgery

  

0.001

 

<0.001

   Yes, curative resection

41 (84)

51.1 (36.5–73.7)

 

235.0 (172.3–331.9)

 

   No, or palliative

8 (16)

162.9 (68.8–346.4)

 

971.7 (306.1–2290.4)

 
  1. Clinico-pathological characteristics and pre-operative CK18-Asp396 and total CK18 plasma levels. P-values were calculated with Kruskal-Wallis and Mann-Whitney tests and P ≤ 0.05 were considered significant, shown in bold. * Some values missing.