Aberrant expression of UbcH10 in cancer. (A) Immunohistochemical analysis of the UbcH10-expression profile in various types of cancer including 16 different organs revealed that UbcH10 is highly expressed in cancer compared with its adjacent non-malignant tissues of the colon, breast, lung, ovary, thymus, and uterine cervix. (B) Summary of the UbcH10-expression profile in human tissues. Statistically significant differences were observed in the UbcH10 level between cancer and normal adjacent tissues. (C) Representative picture of the immunohistochemical analysis using normal colon epithelia and colon cancer tissue. UbcH10 is markedly expressed in colon cancer compared with normal colon epithelia. (D) Results of the immunostaining with UbcH10 in colon cancer. Higher levels of UbcH10 appeared in cancer, and it was mainly localized to the nucleus.