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Table 2 Clinical characteristics and YKL-40 expression in tumor tissue and plasma YKL-40 levels from patients diagnosed with ovarian cancer#

From: YKL-40 tissue expression and plasma levels in patients with ovarian cancer

Characteristic   YKL-40 protein expression (N = 473)   Plasma YKL-40 (μg/l) (N = 76)
  N (%) Median (range) N (%) Median (range)
FIGO stage:     
I 157 (33) 10 (0–90) 17 (22) 59 (20–340)
II 48 (10) 5 (0–30) 4 (5) 53 (39–259)
III 245 (52) 10 (0–70) 47 (62) 168 (32–1808)
IV 23 (5) 20 (5–40) 8 (11) 320 (86–2650)
Histological type of tumor:     
Undifferentiated carcinoma 9 (2) 20 (0–40) 3 (4) 576 (156–1808)
Adenocarcinoma (NOS) 23 (5) 10 (0–30) 5 (6) 452 (237–2650)
Serous adenocarcinoma 249 (53) 5 (0–70) 50 (66) 112 (20–548)
Mucinous adenocarcinoma 53 (11) 10 (0–80) 7 (9) 102 (20–856)
Endometroid adenocarcinoma 69 (15) 10 (0–90) 8 (11) 93 (29–193)
Clear-cell neoplasm 46 (10) 10 (0–40) 2 (3) 220 (59–380)
No information - - 1 (1) 340
Histological grade of tumor:     
Grade 1 124 (26) 10 (0–60) 17 (22) 61 (20–356)
Grade 2 165 (35) 10 (0–80) 27 (36) 162 (32–856)
Grade 3 183 (39) 10 (0–90) 26 (34) 144 (20–2650)
No information - - 6 (8) 360 (29–1808)
  1. # Scoring for YKL-40 expression was based on the proportion of cells in a given tumor specimen exhibiting distinct cytoplasmic immunopositivity as well as intensity of staining percentage scale: 0, 5, 10, 20, 30, 40, 50, 60, 70, 80, 90, and 100. The YKL-40 scoring results was transformed into a four-tiered scale: 1 = negative; 2 = 5% positive tumor cells; 3 = 10% positive tumor cells and 4 = 20% or more positive tumor cells.