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Figure 4 | BMC Cancer

Figure 4

From: The high affinity selectin glycan ligand C2-O-sLex and mRNA transcripts of the core 2 β-1,6-N-acetylglusaminyltransferase (C2GnT1) gene are highly expressed in human colorectal adenocarcinomas

Figure 4

Moderately differentiated human colorectal adenocarcinomas expressed high levels of C2-O-sLe x. (A) A graph of the number of neoplastic cells in well, moderately, and poorly differentiated colorectal adenocarcinomas that were positive for expression of CHO-131 mAb at low (0+ to 1+ staining intensity) and high (2+ to 3+ staining intensity) levels. (B) A graph of the percentage of colorectal adenocarcinomas that were highly positive for C2-O-sLex compared to sLex; n = 22, n = 83, and n = 8 for well, moderately, and poorly differentiated colorectal adenocarcinomas stained with CHO-131 mAb that detected C2-O-sLex; n = 11, n = 112, and n = 11 for well, moderately, and poorly differentiated colorectal adenocarcinomas stained with CSLEX1 mAb that detected sLex. *Moderately differentiated colorectal adenocarcinomas expressed significantly higher levels of C2-O-sLex than well differentiated carcinomas by the Pearson's chi-squared test, p = 0.04.

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