Skip to main content
Figure 3 | BMC Cancer

Figure 3

From: Genes of cell-cell interactions, chemotherapy detoxification and apoptosis are induced during chemotherapy of acute myeloid leukemia

Figure 3

Gene ontology analysis of chemotherapy induced genes. Gene ontology (GO) annotations associated with overexpressed genes that significantly discriminate between Early (2–4 h) and Late (18–24 h) responses were determined using the Source database http://source.stanford.edu and iterative group analysis (iGA) [22]. All overexpressed genes in the array were analyzed to determine gene products associated with any GO-term. The significant annotations consisting of genes found to be significantly up- or downregulated for early and late response were selected by use of 100 permutations. The threshold for significant GO annotations was set to p-value 4.5E-4. Number of genes (%), horizontal axis, represents the proportion of the identified genes belonging to each GO term that significantly changed their expression at early or late timepoints after start of chemotherapy.

Back to article page