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Table 5 Pharmacokinetic analysis- Population estimates for radioactivity following administration of the therapeutic dose of I131 KAb201.

From: Randomised Phase I/II trial assessing the safety and efficacy of radiolabelled anti-carcinoembryonic antigen I131KAb201 antibodies given intra-arterially or intravenously in patients with unresectable pancreatic adenocarcinoma

Parameter

 

Intra-arterial group

Intravenous group

Volume of distribution

mean(SE)

0.0600 (0.0048) L

0.0611 (0.0024) L

Elimination rate

mean(SE)

0.1461 (0.0179) litres/hour1

0.1992 (0.0224) litres/hour

Area under Curve

mean (range)

5509.0 (3245.3, 11049.7) ng/ml

4854.9 (3482.6, 6272.5) ng/ml

Cmax

mean (range)

806.0 (608.8, 1191.4) ng/ml

982.2 (754.4, 1386.9) ng/ml

  1. SE = standard error; L = litre; h = hour; ng = nanogram; ml= millilitres.