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Table 5 Pharmacokinetic analysis- Population estimates for radioactivity following administration of the therapeutic dose of I131 KAb201.

From: Randomised Phase I/II trial assessing the safety and efficacy of radiolabelled anti-carcinoembryonic antigen I131KAb201 antibodies given intra-arterially or intravenously in patients with unresectable pancreatic adenocarcinoma

Parameter   Intra-arterial group Intravenous group
Volume of distribution mean(SE) 0.0600 (0.0048) L 0.0611 (0.0024) L
Elimination rate mean(SE) 0.1461 (0.0179) litres/hour1 0.1992 (0.0224) litres/hour
Area under Curve mean (range) 5509.0 (3245.3, 11049.7) ng/ml 4854.9 (3482.6, 6272.5) ng/ml
Cmax mean (range) 806.0 (608.8, 1191.4) ng/ml 982.2 (754.4, 1386.9) ng/ml
  1. SE = standard error; L = litre; h = hour; ng = nanogram; ml= millilitres.