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Table 2 Association between c-erbB-2 expression and clinicopathological data in 185 cases of ESCC analyzed by TMA

From: Evaluation of gene amplification and protein expression of HER-2/neu in esophageal squamous cell carcinoma using Fluorescence in situ Hybridization (FISH) and immunohistochemistry

Variables Category c-erbB-2
   Negative
[0 and 1+]
(%)
Positive
[2 and 3+]
(%)
Total p value
Gender Male 97 (82.9) 52 (76.5) 149 0.337
  Female 20 (17.1) 16 (23.5) 36  
Age < 60 years 61 (54.5) 46 (69.7) 107 0.057
 60 years 51 (45.5) 20 (30.3) 71  
Ethnicity Caucasian 84 (77.1) 52 (77.6) 136 1.000
  No Caucasian 25 (22.9) 15 (22.4) 40  
Tumor location Upper 18 (16.2) 12 (18.8) 30 0.781
  Middle 65 (58.6) 34 (53.1) 99  
  Lower 28 (25.2) 18 (28.1) 46  
Histological grade G1+G2 87 (74.4) 57 (83.8) 144 0.147
  G3+G4 30 (25.6) 11 (16.2) 41  
Infiltration level Basal layer 5 (4.3) 0 (0) 5 NA
  Muscular 22 (18.8) 17 (25) 39  
  Adventitia 90 (76.9) 51 (75) 141  
Lymphatic invasion Not observed 30 (25.6) 19 (27.9) 49 0.733
  Present 87 (74.4) 49 (72.1) 136  
Venous invasion Not observed 95 (81.2) 54 (79.4) 149 0.848
  Present 22 (18.8) 14 (20.6) 36  
pN Negative 63 (53.8) 36 (52.9) 99 1.000
  Positive 54 (46.2) 32 (47.1) 86  
Surgical margins Not committed 110 (95.7) 67 (98.5) 177 NA
  Committed 5 (4.3) 1 (1.5) 6  
Stage 1+2 58 (49.6) 27 (39.7) 85 0.222
  3+4 59 (50.4) 41 (60.3) 100  
Recurrence Negative 49 (42.6) 28 (41.8) 77 1.000
  Positive 66 (57.4) 39 (58.2) 105  
  1. NA: not available