Stages and pathways of GFAP+NNP and GBM cells differentiation. a, GFAP+NNP cells coexpress Nestin (NST), Fibronectin (FIBRO), GFAP, MAP2, CD44 and Beta III-tubulin. Neural intermediants express GFAP, MAP2, Nestin and Beta III-tubulin. Neuronal cells express MAP2, Beta III-tubulin. Glial cells coexpress GFAP, Nestin and CD44. Non-neural cells express CD44 and Fibronectin. b, in GBM cells the mesenchymal differentiation is very advanced; neural differentiation is arrested at early stages.