Figure 5

Anti-proliferative effect of AZD0530 in combination with Imatinib. Effects of AZD0530 and Imatinib as single agents or in combination on the proliferation of BV173 (A), parental WTSupB15 (B) and Imatinib resistant RTSupB15 (C) cell lines. Combining AZD0530 with Imatinib had an additive effect only in BV173 cells. All three cell lines were plated in duplicates at the indicated concentrations, and proliferation was assessed after three days by dye exclusion of viable cells. Results represent the mean of 3 independent experiments +/- S.D.