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Figure 1 | BMC Cancer

Figure 1

From: The effect of the dual Src/Abl kinase inhibitor AZD0530 on Philadelphia positive leukaemia cell lines

Figure 1

Effects of AZD0530 on proliferation. A AZD0530 specifically blocks the proliferation of Ph+ BV173 cells in a dose dependent manner, while the proliferation of the Ph- SEM cells is not markedly affected. B AZD0530 inhibited proliferation of WTSupB15, in a dose-dependent way. No effect was observed on the proliferation of RTSupB15 upon treatment with AZD0530. C AZD0530 inhibited the proliferation of Ba/F3 cells expressing WTp185Bcr-Abl and the Bcr-Abl Mut Y253F. Ba/F3 cells expressing the Bcr-Abl Mut E255K were less sensitive to AZD0530 as compared to Mut Y253F and cells expressing Bcr-Abl Mut T315I were stable in the presence of AZD0530. All cell lines were treated with the indicated concentrations of AZD0530 for three days and proliferation was determined by trypan blue exclusion of viable cells. Results are the mean values of 3 independent experiments carried out in duplicates +/- S.D.

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