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Figure 7 | BMC Cancer

Figure 7

From: Gain in cellular organization of inflammatory breast cancer: A 3D in vitro model that mimics the in vivo metastasis

Figure 7

Nuclear translocation of E-cadherin upon disruption of intact axis: (Red channel; E-cadherin 1° antibody conjugated to 568 nm fluorophore, Green channel; β-catenin 1° antibody conjugated to a 488 nm fluorophore). (3 HR) Co-localization of E-cadherin and β-catenin at the plasma membrane is seen. (6 HR 24 HR) Prolonged disruption results in E-cadherin nuclear translocation. (10 HR 24 HR) Membrane degeneration is observed.

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