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Table 6 Cox regression analysis showing association between survival and relative changes in biomarkers.

From: Pre-radiotherapy plasma carotenoids and markers of oxidative stress are associated with survival in head and neck squamous cell carcinoma patients: a prospective study

Variables

Crude

Adjusted

 

Hazard rate ratio

95% CI

p-value

Hazard rate ratio

95% CI

p-value

Progression-free survival

d-ROMs increase

0.33

0.14-0.76

0.01

0.31

0.13-0.76

0.01a

8-iso PGF2α

increase

0.48

0.22-1.08

0.08

0.51

0.22-1.17

0.11b

FRAP decrease

0.43

0.19-0.98

0.05

0.42

0.17-0.998

0.05c

Overall survival

d-ROMs increase

0.26

0.08-0.80

0.02

0.31

0.10-1.00

0.05a

8-iso PGF2α

increase

0.54

0.21-1.42

0.21

0.58

0.21-1.59

0.29b

FRAP decrease

0.39

0.14-1.10

0.07

0.52

0.18-1.56

0.25c

  1. The above median relative changes in plasma levels of oxidative stress biomarkers (d-ROMs and 8-iso PGF2α) and total antioxidant capacity FRAP are compared with below median relative changes in the plasma levels of the corresponding biomarkers in 57 patients for progression-free and overall survivals.
  2. aThe analysis are adjusted for stage, smoking status and tumour localization
  3. bThe analysis are adjusted for stage, smoking status and age
  4. cThe analysis are adjusted for stage, tumour localization and BMI
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BMC Cancer

ISSN: 1471-2407

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