Reproducibility of the methylation estimates for the FFPE samples by SMART-MSP. Plots of the absolute difference between the highest and lowest possible methylation estimate divided by the average methylation estimate against the age of the samples for each gene are shown. A. The CDKN2A assay. B. The RARB assay. It is observed that the overall reproducibility is better for the CDKN2A assay compared to the RARB assay. It can also be observed that the reproducibility did not depend on the age of the samples.