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Table 3 Immunohistochemistry (IHC) and fluorescence in-situ hybridization (FISH) results for HER2 protein expression and gene amplification respectively with amplification (in bold) observed in 3/16 (18.8%) mucinous borderline tumors of the ovary.

From: HER2 overexpression and amplification is present in a subset of ovarian mucinous carcinomas and can be targeted with trastuzumab therapy

ID

IHC (HER2)

HER2/CEP 17 Ratio

IHC/FISH concordance

VB1

0

0.9

 

VB2

0

0.8

 

VB3

0

0.8

 

VB4

1

1.2

 

VB5

0

1.2

 

VB6

0

1.0

 

J1

3

3.2

 

J2

0

0.8

 

J3

0

1.2

 

J4

0

1.1

 

J5

0

1.1

 

J6

0

1.2

 

J7

0

2.4

Discordant

J8

2

3.1

 

J9

0

1.3

 

J10

0

1.3