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Table 2 Immunohistochemistry (IHC) and fluorescence in-situ hybridization (FISH) results for HER2 protein expression and gene amplification respectively with amplification (in bold) observed in 6/33 (18.2%) mucinous carcinomas.

From: HER2 overexpression and amplification is present in a subset of ovarian mucinous carcinomas and can be targeted with trastuzumab therapy

ID

IHC (HER2)

HER2/CEP 17 Ratio

Patient Outcome

IHC/FISH concordance

V1

0

0.8

  

V2

3

8.0

  

V3

0

1.0

  

V4

0

1.1

  

V5

3

5+

  

V6

3

5.5

  

V7

0

1.1

  

V8

1

1.9

  

V9

0

1.2

  

V10

0

6.7

 

Discordant

V11

0

1.0

  

V12

0

0.7

  

V13

0

1.0

  

V14

0

0.9

Recurrent

 

V15

0

1.1

  

V16

0

1.1

  

V17

0

1.4

Recurrent

 

V18

0

1.3

Recurrent

 

V19

1

0.8

Recurrent

 

V20

2

6.2

  

V21

0

1.5

Recurrent

 

V22

0

1.2

  

V23

0

1.2

  

V24

0

1.7

Recurrent

 

V25

0

1.1

  

V26

0

0.9

  

V27

0

1.0

Recurrent

 

V28

3

5.1

  

V29

1

1.3

  

V30

0

1.0

  

V31

0

1.2

Recurrent

 

V32

0

1.4

Recurrent

 

V33

0

1.0

Recurrent