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Table 1 Relationship between CRC clinicopathologic features and ST6Gal I activity

From: Synthesis and expression of CDw75 antigen in human colorectal cancer

ST6Gal Activity

 

Tumor

p

Tumor/Healthy

p

Net increase

p

n

 

Means ± SEM

 

Means ± SEM

 

Means ± SEM

  

Age (years)

       

< 69

61.89 ± 13.17

0.887

2.21 ± 0.52

0.981

54.52 ± 12.25

0.042

9

69-77

58.85 ± 15.18

 

4.25 ± 1.99

 

62.25 ± 21.74

 

9

> 77

38.48 ± 6.75

 

2.60 ± 0.89

 

20.23 ± 6.04

 

10

Tumour location

       

Proximal

41.36 ± 9.28

0.231

2.21 ± 0.87

0.442

28.09 ± 10.11

0.308

7

Distal

72.12 ± 12.58

 

3.54 ± 1.35

 

63.46 ± 14.78

 

13

Rectum

34.56 ± 8.03

 

2.01 ± 0.69

 

25.99 ± 9.26

 

7

Size (cm)

       

<4

69.89 ± 18.74

0.130

4.96 ± 2.28

0.033

56.86 ± 20.75

0.727

9

4-5

41.45 ± 9.07

 

1.49 ± 0.320

 

37.00 ± 13.83

 

9

> 5

55.81 ± 8.42

 

3.60 ± 1.17

 

38.47 ± 6.35

 

9

Histologic type

       

Poorly differentiated

8.27

0.208

1.49

0.371

2.72

0.156

1

Moderately differentiated

57.66 ± 7.63

 

3.27 ± 0.80

 

49.01 ± 8.99

 

24

Well differentiated

25.34 ± 0.98

 

0.80 ± 0.28

 

2.16

 

1

Growth type

       

Polypoid

47.28 ± 10.13

0.915

1.83 ± 0.39

0.414

36.93 ± 11.41

0.716

12

Non polypoid

34.31 ± 11.21

 

2.75 ± 1.16

 

23.24 ± 11.56

 

4

TNM classification

       

T

       

T1/T2

76.09 ± 30.13

0.223

3.68 ± 2.25

0.510

74.94 ± 38.60

0.421

3

T3

54.12 ± 8.08

 

3.12 ± 0.87

 

43.97 ± 9.65

 

33

T4

29.00 ± 9.49

 

1.33 ± 0.58

 

22.63 ± 19.91

 

4

N

       

N0

59.90 ± 10.26

0.139

3.27 ± 1.08

0.443

47.34 ± 11.58

0.491

24

N1

55.83 ± 14.00

 

3.53 ± 1.50

 

51.26 ± 16.17

 

9

N2

27.19 ± 6.90

 

1.26 ± 0.33

 

18.07 ± 12.27

 

7

M

       

M0

55.76 ± 7.60

0.616

3.16 ± 0.79

0.254

46.42 ± 8.92

-

37

M1

24.93

 

0.62

 

-

 

1

AJCC classification

       

I

76.09 ± 30.13

0.146

3.68 ± 2.25

0.597

74.94 ± 38.60

0.407

3

IIa

60.05 ± 11.39

 

3.30 ± 1.27

 

46.63 ± 12.82

 

20

IIb

13.17 ± 4.90

 

0.89 ± 0.59

 

2.72

 

2

IIIb

59.70 ± 15.26

 

3.89 ± 1.66

 

51.26 ± 16.17

 

8

IIIc

28.72 ± 7.96

 

1.42 ± 0.34

 

18.07 ± 12.27

 

6

IV

-

 

0.62

 

-

 

1

  1. Relationship between CRC patient's clinicopathologic features and tumour stading and ST6Gal I activity. Tumour/Healthy represents the quotient of the enzyme activity from the two tissues of the same patient. Net increase represents the difference of the enzyme activity from tumour and healthy tissues from the same patient. The ST6Gal I activity and the net increase are expressed as μU/mg protein. Data are represented as means ± SEM (standard error of the means) of the n patients analyzed. p was obtained from the Mann-Whitney U test (for tumour growth type) and Kruskall-Wallis test (for the rest of variables).
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