Skip to main content

Table 3 Ingenuity Pathway Analysis, molecular interactions and networks

From: Inverse correlation between PDGFC expression and lymphocyte infiltration in human papillary thyroid carcinomas

ID Molecules in Network Score Top Functions
1 ALP, ANXA6, C1R, CD37, COL5A1, CXCL9, CXCL10, ERK, FCER1G, Ifn gamma, Ige, IGFBP5, IgG, IGHG1, IGL@, Igm, IL12, IL2RG, IL7R, Interferon alpha, JAG1, MAFB, MBL2, MHC Class II, Notch, NOTCH1, NOTCH3, NTN4, OXTR, PDGFC, SET, TGFB3, TNFRSF17, TNFSF13B, ZNF354C 44 Hematological System Development and Function, Tissue Development, Cellular Growth and Proliferation
2 ABCD3, CACYBP, CD3, CSF2RB, CXCL5, IFN Beta, IL1, IL32, IL23A, ISG15, JAK, KYNU, LCP2, LSP1, LTA, LTB, NF-κB, NFAT complex, NFkB, NGFR, NPM1 (includes EG:4869), peptidase, PPIF, PSCDBP, REN, RIPK4, S100B, STAT4, TLR5, Tnf receptor, TNFAIP3, TYROBP, UBA7, VAV, VAV1 44 Hematological System Development and Function, Immune and Lymphatic System Development and Function, Tissue Morphology
3 ACTA2 (includes EG:59), Akt, Ap1, Calpain, CAPN3, CD4, CD53, COL4A2, COTL1, Cpla2, DOCK10, ENG, F Actin, FYB, HLA-DQB1, IL10RA, Integrin, LDL, MB, Myosin, NCK, Nfat, Pdgf, PER2, PER3, Pkc(s), Ras, SHROOM3, SUB1, SYF2, TCR, Tgf beta, TRA@, VCAM1, WIPF1 32 Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune and Lymphatic System Development and Function
4 AOF2, BAZ2A, BIRC5, Caspase, CBL, CCNA2, Cytochrome c, ELP3, GZMK, HCLS1, HIF1A, Histone h3, Hsp70, Hsp90, IFI27, IL2RB, Insulin, Mapk, NFKBIA, NR2F2, P38 MAPK, PFN1, PI3K, PLA2G7, Proteasome, RAD23B, RNA polymerase II, STAT, STAT1, STAT5a/b, UBD, Ubiquitin, Vegf, VIP, ZNF83 32 Cell Cycle, Cardiac Hypertrophy, Cardiovascular Disease
5 Actin, BST2, C1R, CAMSAP1, CAP2, CCL17, CXCL9, DUSP5, FCGR2B, HLA-DMA, HLA-DOA, HLA-DQB1, HLA-DQB2, HMGN3, IFI44L, IFNG, IL17F, IL18R1, IL18RAP, IL1B, IL23A, LCP1, MARCH5, NFYB, PDE4B, PLEK, PRPF40A, PXMP3, RAB8B, SF1, SMAD1, SP110, SPAG16, TREM2, TYMP 28 Immunological Disease, Immune Response, Connective Tissue Disorders
6 ABCD3, AHNAK, ARMCX3, ATF7IP, ATPase, BNIP3 (includes EG:664), C3, CLTC, COL4A2, COTL1, DAB2, ECM2, FBXO4, FBXO21, GRPEL1, HLTF, IFITM1, IKZF1, IKZF3, KIF1B, MYH6, NAE1, NEDD8, PPP2R4, retinoic acid, RNF10, SFTPC, SKP1, SMARCA4, SMARCA5, TERF1, TMEM150, UBE2M, VCAM1, VHL 22 Cell Cycle, Cellular Assembly and Organization, DNA Replication, Recombination, and Repair
7 BCL2L1, COL6A1, COL6A2, EGFR, ERBB2, FOXN2, FYB, GALNT10, GKAP1, GULP1, HBB (includes EG:3043), HGS, HP, HPR, ITGB1, KRT7, LTA, LTB, MIST, MYST1, NFIB, NPTN, NUP210, PLAC8, POLD1, PTPRA, PTPRS (includes EG:5802), SH3BGRL, SKAP1, THBS2, TP53, TRIM22, UPF3A, WAP, ZFP36L2 22 Immune and Lymphatic System Development and Function, Tissue Development, Cancer
8 ADSSL1, ANG, APOD, ARNT2, beta-estradiol, bilirubin, C3, CACNG1, CALCR, CGRRF1, ESR2, GARS, GYPA, HGF, IPO7, LCAT, MAMLD1, NPM1 (includes EG:4869), OCLN, PLEKHA4, POLD4, PRIM2, PTPN2, RAP1GAP (includes EG:5909), RBM9, RBM17, RGS3, RPL5, S100A13, SFRS10, SNAP25, STX4, STX1A, STXBP6, YWHAZ 18 Drug Metabolism, Molecular Transport, Small Molecule Biochemistry
9 AEBP1, CD79A, CD79B, CDC34 (includes EG:997), CDC45L, CDON, CHST10, EBF1, FSH, GATAD2A, GFI1, GLRX, H2-M1, HLA-B, hydrogen peroxide, IDH2, IGHM, IGLL1, INSM1, KIAA0247, MAN2A1, MBD2, MIF, MYC, NEO1, PHKA2, SERINC3, TCF3, TERT, TGFBR3, UBE2L3, VPREB1 (includes EG:7441), YAF2, ZBTB7A, ZRANB1 18 Cellular Development, Hematological System Development and Function, Immune and Lymphatic System Development and Function
  1. Ingenuity Pathway Analysis of 189 genes returned a number of networks of molecular interactions and functions. Here is listed the top nine networks. Molecules in each network is listed, Network Eligible Molecules appear in bold, while other molecules are in regular font. Score and Top Functions is as defined by Ingenuity Pathway Analysis.