Inverse correlation between PDGFC expression and lymphocyte infiltration in human papillary thyroid carcinomas

BMC Cancer

Table 1 Histopathological evaluation

Biopsy	Group²	Histology¹	L-score⁶	pTpNM-stage (age, sex)	Relapse (years)³	Tumour⁴	Obs. (years)
181-I		PTC	L0	T_2AN₀M₀, (37, M)	No	PT	15
197-I		PTC-FV, thyroiditis	L2	T_1BN₀M₀, (50, M)	No	PT	14
198-IV		PTC, some histologic dediff.	L0	T_2AN_1BM₀, (13, F)	No	PT	14
219-II	PTC(diff)	PTC	L0	T_4AN₀M₀, (67, M)	No	PT	6.0 (dead)⁵
222-IV		PTC	L0	T_1BN_1BM₀, (37, F)	No	PT	14
283-III		PTC, thyroiditis	L1	T_2AN_1BM₀, (22, F)	No	PT	12
300-V		PTC, squamous cell metaplasia	L1	T_3AN₀M₀, (43, F)	No	PT	11
317-IV		PTC	L0	T₁N_1AM₀, (30, F)	LN (9.1)	LN (r)	11
328-V		PTC	L0	T_2BN_1AM₀, (27, F)	No	PT	10
353-I		PTC-FV	L0	T_3BN₀M₀, (70, M)	No	PT	9.0 (dead)
246-I		PTC-R-M1	L0	T_4AN_1AM₀, (79, F)	LN, Lung (4.7)	LN (r)	9.0 (dead)
247-IV		PTC-PD-M1, thyroiditis	L2	T_4AN_1AM₁, (83, F)	Lung metastases at diagnosis	PT	0.4 (dead)
319-V		PTC-PD	L1	T_4AN_1AM₀, (79, F)	Residual tumour in trachea	LN	2.0 (dead)
326-III	PTC(agg)	PTC-UD-M1	L0	T_4AN_1AM₁, (72, M)	Lung metastases at diagnosis	PT	0.1 (dead)
345-III		PTC-PD, squamous cell metaplasia	L1	T_1BN_1BM₀, (37, M)	LN	LN	3.4 (dead)
354-II		PTC-PD	L0	T_4AN₀M₀, (80, F)	No	PT	10
367-I		PTC-PD-R-M1	L0	T_4AN₀M₁, (81, F)	Lung metastases at diagnosis	LN	1.3 (dead)
379-I		PTC-PD	L1	T_4BN_1BM₀, (74, F)	No	PT	9.0

¹:PTC: papillary thyroid carcinomas; FV: follicular variant; PD: poorly differentiated; UD: undifferentiated; R: relapse tumour; M1: presence of distant metastases. Representativity was assessed by histopathologic analysis from the immediate vicinity (neighbour section) to the biopsy used for extraction of total RNA. ²: PTC (diff): differentiated, with or without lymph node metastases; PTC (agg): poorly differentiated, or relapse tumour with synchronous distant metastases.
³: time from initial surgery to relapse (years). ⁴: PT: primary tumour; LN: lymph node metastasis in the neck, (r) = relapse. Biopsy 317 IV was not included in the microarray data. ⁵: Patient died from lung cancer not related to PTC. ⁶Semiquantitativ assessment of number of lymphocytes present in the biopsies: L0 = practically no lymphocytes, L1 = less than 10% of total number of cells, L2 = between 10-50% of total number of cells, L3 more than 50% of total number of cells. ⁷Section facing the part of the biopsy used for RNA extraction was classified as L0. Examination of two other sections taken from other parts of the same tumour revealed tumour-infiltrating lymphocytes (both classified as L1), also extending into the non-neoplastic surrounding tissue.

ISSN: 1471-2407