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Table 3 TP53 mutation and allelism (n = 211)

From: Identification of colorectal cancer patients with tumors carrying the TP53mutation on the codon 72 proline allele that benefited most from 5-fluorouracil (5-FU) based postoperative chemotherapy

 

No mutation

Mutation on Arg

Mutation on Pro

P value

Case, n (%)

64 (30.3)

93 (44.1)

54 (25.6)

 

Primary tumor location, n (%)

    

   Colon

35 (31.0)

51 (45.1)

27 (23.9)

 

   Rectum

29 (29.6)

42 (42.9)

27 (27.6)

0.832

Site, n (%)

    

   Proximal

18 (36.7)

17 (34.7)

14 (28.6)

 

   Distal

17 (26.6)

34 (53.1)

13 (20.3)

0.149

Histopathological grade, n (%)

    

   G1+G2

50 (28.1)

79 (44.4)

49 (27.5)

 

   G3

14 (42.4)

14 (42.4)

5 (15.2)

0.167

Lymph node metastasis, n (%)

    

   N0

43 (40.6)

39 (36.8)

24 (22.6)

 

   N1

16 (19.0)

45 (53.6)

23 (27.4)

 

   N2

5 (23.8)

9 (42.9)

7 (33.3)

0.022*

Dukes' stage, n (%)

    

   A

19 (45.2)

15 (35.7)

8 (19.0)

 

   B

23 (38.3)

21 (35.0)

16 (26.7)

 

   C

12 (16.0)

42 (56.0)

21 (28.0)

 

   D

10 (29.4)

15 (44.1)

9 (26.5)

0.024*

  1. * The statistical difference is shown by the chi-square test.