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Table 5 Multivariate analyses of factors associated with survival and recurrence

From: Hypoxia-inducible factor-1 alpha, in association with inflammation, angiogenesis and MYC, is a critical prognostic factor in patients with HCC after surgery

  Hazard ratio (95%CI) P
OS   
AFP(ng/ml) (≤ 20 vs. >20) 1.320 (0.666-2.615) 0.426
γ-GT(U/I) (≤ 54 vs. >54) 2.098 (1.073-4.103) 0.030
Tumor differentiation (I+II vs. III+IV) 1.228 (0.661-2.279) 0.516
Tumor size (cm) 1.102 (1.016-1.196) 0.020
Vascular invasion (no vs. yes) 4.351 (1.992-9.500) 0.001
Capsule (complete vs. no) 0.676 (0.332-1.375) 0.280
HIF-1α mRNA (low vs. high) 2.167 (1.185-3.965) 0.012
COX-2 mRNA (low vs. high) 2.557 (1.355-4.824) 0.004
MMP7 mRNA (low vs. high) 2.287 (1.217-4.301) 0.010
PDGFRA mRNA (low vs. high) 2.320 (1.225-4.394) 0.010
HIF-1α protein (low vs. high) 2.108 (1.120-3.969) 0.021
DFS   
Age (year) 0.990 (0.963-1.018) 0.475
AFP(ng/ml) (≤ 20 vs. >20) 1.707 (0.903-3.227) 0.100
Tumor size (cm) 1.090 (0.997-1.191) 0.060
Tumor number (single vs. multiple) 3.324 (1.818-6.079) 0.001
Vascular invasion (no vs. yes) 2.453 (1.192-5.047) 0.015
Encapsulation (complete vs. no) 1.573 (0.781-3.168) 0.204
HIF-1α mRNA (low vs. high) 2.359 (1.325-4.201) 0.004
COX-2 mRNA (low vs. high) 2.170 (1.201-3.921) 0.010
MMP7 mRNA (low vs. high) 1.499 (0.830-2.707) 0.179
VEGF mRNA (low vs. high) 1.702 (0.936-3.094) 0.081
PDGFRA mRNA (low vs. high) 1.910 (1.038-3.514) 0.038
HIF-1α protein (low vs. high) 2.265 (1.251-4.009) 0.007
  1. Detailed legends: The P values were calculated using multivariate Cox proportional hazards analysis. Variables were adopted for their prognostic significance by univariate analysis and no significant correlation between each other. COX-2 mRNA, PDGFRA mRNA, MMP7 mRNA, VEGF mRNA and HIF-1α protein were presented in different multivariable analysis respectively. (For details see Additional files 3, 4, 5, 6, 7 and 8)