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Table 4 Univariate analyses of factors associated with survival and recurrence

From: Hypoxia-inducible factor-1 alpha, in association with inflammation, angiogenesis and MYC, is a critical prognostic factor in patients with HCC after surgery

Variables OS DFS
  Hazard ratio(95%CI) P Hazard ratio(95%CI) P
Age (year) 0.982 (0.958-1.006) 0.142 0.976 (0.953-0.999) 0.043
Sex (female vs. male) 0.630 (0.250-1.588) 0.298 0.673 (0.288-1.574) 0.361
Hepatitis history (no vs. yes) 1.384 (0.498-3.848) 0.534 0.874 (0.395-1.935) 0.739
Liver cirrhosis (no vs. yes) 1.855 (0.746-4.657) 0.190 0.904 (0.455-1.797) 0.773
AFP(ng/ml) (≤ 20 vs. >20) 2.183 (1.175-4.035) 0.013 2.553 (1.401-4.651) 0.002
ALT(U/L) (≤ 40 vs. >40) 0.877 (0.502-1.533) 0.645 0.817 (0.476-1.401) 0.463
γ-GT(U/L) (≤ 54 vs. >54) 2.475 (1.313-4.664) 0.005 1.555 (0.888-2.722) 0.123
Tumor differentiation (I+II vs. III+IV) 1.860 (1.062-3.297) 0.030 1.180 (0.691-2.014) 0.545
Tumor size (cm) 1.179 (1.109-1.253) 0.001 1.152 (1.083-1.226) 0.001
Tumor number (single vs. multiple) 1.597 (0.860-2.966) 0.138 2.851 (1.611-5.046) 0.001
Vascular invasion (no vs. yes) 5.706 (2.971-10.960) 0.001 4.028 (2.288-7.089) 0.001
Encapsulation (complete vs. no) 2.060 (1.135-3.737) 0.017 3.273 (1.773-6.044) 0.001
BCLC stage (A vs. B+C) 6.225 (2.645-14.647) 0.001 2.601 (1.390-4.867) 0.003
COX-2 mRNA (low vs. high) 2.042 (1.157-3.604) 0.014 1.839 (1.068-3.167) 0.027
MMP7 mRNA (low vs. high) 2.278 (1.297-4.001) 0.004 0.753 (0.409-1.384) 0.060
MMP9 mRNA (low vs. high) 0.740 (0.412-1.328) 0.313 1.711 (0.977-2.995) 0.609
VEGF mRNA (low vs. high) 1.370 (0.756-2.483) 0.299 1.906 (1.096-3.126) 0.022
PDGFRA mRNA (low vs. high) 1.801 (1.017-3.188) 0.044 1.771 (1.023-3.066) 0.041
MYC mRNA (low vs. high) 0.948 (0.517-1.735) 0.862 0.867 (0.501-1.499) 0.361
HIF-1α mRNA (low vs. high) 2.644 (1.524-4.655) 0.001 2.514 (1.462-4.324) 0.001
HIF-1α protein (low vs. high) 1.874 (1.074-3.270) 0.027 2.004 (1.167-3.440) 0.012
  1. Detailed legends: The P values were calculated using univariate Cox proportional hazards analysis. Cut-point values of the experiment results were determined by the X-tile software.