Table 2 Correlations of HIF-1α mRNA and protein with clinicopathological characters

Patients

68

42

71

39

Age(years)

   ≤52

28

26

0.049

32

22

0.320

   >52

40

16

39

17

Sex

   Male

57

38

0.40

57

38

0.017

   Female

11

4

14

1

Hepatitis history

   Yes

61

39

0.739

62

38

0.094

   No

7

3

9

1

Preoperative AFP(ng/ml)

   ≤20

29

16

0.693

33

12

0.156

   >20

39

26

38

27

Liver cirrhosis

   Yes

59

34

0.428

56

37

0.029

   No

9

8

15

2

ALT(U/L)

   ≤40

36

22

1.000

38

20

0.844

   >40

32

20

33

19

Γ-GT(U/L)

   ≤54

30

14

0.318

31

13

0.316

   >54

38

28

40

26

Tumor size (cm)

   ≤5

35

21

1.000

33

23

0.236

   >5

33

21

38

16

Tumor encapsulation

   Yes

31

18

0.845

32

17

1.000

   No

37

24

39

22

Tumor number

   Single

53

32

0.820

56

29

0.638

   Multiple

15

10

15

10

Vascular invasion

   Yes

26

25

0.033

27

24

0.027

   No

42

17

44

15

BCLC stage

   A

30

10

0.041

31

9

0.039

   B + C

38

32

40

30

Tumor differentiation

   I+II

40

18

0.119

36

22

0.690

   III+IV

28

24

35

17

Prophylactic treatment

   Yes

33

22

0.845

31

24

0.110

   No

35

20

39

16