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Table 2 Correlations of HIF-1α mRNA and protein with clinicopathological characters

From: Hypoxia-inducible factor-1 alpha, in association with inflammation, angiogenesis and MYC, is a critical prognostic factor in patients with HCC after surgery

  HIF-1α mRNA HIF-1α protein
  low high P low high P
Patients 68 42   71 39  
Age(years)       
   ≤52 28 26 0.049 32 22 0.320
   >52 40 16   39 17  
Sex       
   Male 57 38 0.40 57 38 0.017
   Female 11 4   14 1  
Hepatitis history       
   Yes 61 39 0.739 62 38 0.094
   No 7 3   9 1  
Preoperative AFP(ng/ml)       
   ≤20 29 16 0.693 33 12 0.156
   >20 39 26   38 27  
Liver cirrhosis       
   Yes 59 34 0.428 56 37 0.029
   No 9 8   15 2  
ALT(U/L)       
   ≤40 36 22 1.000 38 20 0.844
   >40 32 20   33 19  
Γ-GT(U/L)       
   ≤54 30 14 0.318 31 13 0.316
   >54 38 28   40 26  
Tumor size (cm)       
   ≤5 35 21 1.000 33 23 0.236
   >5 33 21   38 16  
Tumor encapsulation       
   Yes 31 18 0.845 32 17 1.000
   No 37 24   39 22  
Tumor number       
   Single 53 32 0.820 56 29 0.638
   Multiple 15 10   15 10  
Vascular invasion       
   Yes 26 25 0.033 27 24 0.027
   No 42 17   44 15  
BCLC stage       
   A 30 10 0.041 31 9 0.039
   B + C 38 32   40 30  
Tumor differentiation       
   I+II 40 18 0.119 36 22 0.690
   III+IV 28 24   35 17  
Prophylactic treatment       
   Yes 33 22 0.845 31 24 0.110
   No 35 20   39 16  
  1. Detailed legends: Fisher's exact tests were used for all the analysis of correlations.