Nuclear detection of Y-boxprotein-1 (YB-1) closely associates with progesterone receptor negativity and is a strong adverse survival factor in human breast cancer

Table 2 Multivariate Cox regression analysis of factors possibly influencing tumor-related survival and recurrence-free survival

				Tumor-related survival				Recurrence-free survival
Name	Variables		Categorisation	Global	Stepwise reverse selection^†			Global	Stepwise reverse selection^†
				p*	Hazard ratio	95% Confidence interval	p	p*	Hazard ratio	95% Confidence interval	p
*Model with dichotomous covariables*
T	Tumor stage	0	pT1-2	0.402		-		0.153		-
		1	pT3-4
N	Lymp node status	0	pN0	0.002	5.050	2.264-11.267	<0.001	0.038	2.934	1.303-6.607	0.009
		1	pN1-3
G	Histologic grade	0	G1-2	0.136	1.875	0.946-3.715	0.072	0.007	3.188	1.442-7.052	0.004
		1	G3
ER	Estrogen receptor status	0	negative	0.168	0.420	0.213-0.829	0.012	0.047	0.357	0.173-0.733	0.005
		1	positive
HER2	HER2 IHC	0	negative (0-1+)	0.386		-		0.045	2.164	1.019-4.594	0.045
		1	positive (2+-3+)
CK5/6	Cytokeratin 5/6 IHC	0	negative (0)	0.085		-		0.305		-
		1	positive (1+-3+)
TP53	TP53 IHC	0	<10%	0.607		-		0.043	0.529	0.256-1.092	0.085
		1	≥ 10%
YB1	YB1 IHC	0	negative (0)	0.530		-		0.738		-
	1	positive (1+-3+)

ISSN: 1471-2407