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Table 1 Clinico-pathological and immunohistochemical parameters in relation to YB-1 immunoreactivity, and univariate analysis of factors regarding tumor-related and recurrence-free surival

From: Nuclear detection of Y-boxprotein-1 (YB-1) closely associates with progesterone receptor negativity and is a strong adverse survival factor in human breast cancer

Variable Categorization Nuclear YB-1 immunoreactivity Tumor-related death Tumor recurrence
   n analyzable neg. pos. p* n events p n events p
Clinico-pathological data:            
Age at diagnosis           
  <50 years 51 43 8 0.036 51 9 0.0064 51 16 0.1895
  ≥ 50 years 108 74 34   108 45   102 42  
Tumor stage           
  pT1 40 35 5 0.004 40 4 <0.0001 39 5 0.0001
  pT2 83 63 20   83 28   81 34  
  pT3 10 4 6   10 4   9 4  
  pT4 26 15 11   26 18   24 15  
Lymph node status           
  pN0 75 60 15 0.101 75 11 <0.0001 74 13 <0.0001
  pN1-3 80 54 26   80 41   76 42  
Histologic grade           
  G1 17 16 1 0.011 17 4 0.0047 17 4 <0.0001
  G2 69 55 14   69 17   65 16  
  G3 73 46 27   73 33   71 38  
Multifocality           
  unifocal tumor 141 104 37 1.000 141 45 0.0903 136 49 0.0683
  multifocal tumor 18 13 5   18 9   17 9  
Histologic type           
  ductal 125 93 32 0.710 125 43 0.9302 123 49 0.5730
  lobular 16 11 5   16 5   14 4  
  other 15 10 5   15 5   13 4  
Immunohistochemistry (IHC):           
Estrogen receptor status           
  negative 42 30 12 1.000 42 19 0.0129 42 24 0.0026
  positive 96 69 27   96 25   92 27  
Progesterone receptor status           
  negative 98 63 35 0.002 98 40 0.0045 93 44 0.0019
  positive 46 41 5   46 8   46 9  
Cytokeratin 5/6 IHC           
  negative (0) 118 85 33 0.540 118 34 0.0100 114 38 0.0349
  positive (1+-3+) 41 32 9   41 20   39 20  
TP53 IHC           
  <10% 85 62 23 1.000 85 28 0.3823 82 28 0.4422
  ≥ 10% 48 31 17   48 18   46 19  
HER2 IHC           
  negative (0-1+) 108 83 25 1.000 108 28 0.0081 102 31 0.0008
  positive (2+-3+) 35 21 14   35 18   35 20  
  1. * Fisher's exact test (two-sided), bold face representing significant data.
  2. Log rank test (two-sided), bold face representing significant data.