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Figure 3 | BMC Cancer

Figure 3

From: Nuclear detection of Y-boxprotein-1 (YB-1) closely associates with progesterone receptor negativity and is a strong adverse survival factor in human breast cancer

Figure 3

Immunohistochemical comparison of different YB-1 antibodies in human invasive breast cancer. While the proliferation marker Ki67 is strongly expressed in a defined fraction of breast tumor cells there is no concordance to the expression pattern of YB-1. The three YB-1 antibodies present very similar expression patterns. However, while the two established polyclonal YB-1 antibodies (#1 is against an N-terminal epitope and available from antibodies-online; #2 has been established by Janz et al. [1]) predominantly detect cytoplasmic YB-1 expression, the newly characterized monoclonal YB-1 antibody Mab F-E2G5 is able to detect nuclear YB-1 besides less abundant expression in the cytoplasm.

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