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Table 4 Interaction between intake of red and processed meat and MDR1 and BCRPpolymorphisms in relation to CRC risk.

From: Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study

 

NCase

NSub-cohort

IRRa

(95% CI)

IRRb

(95% CI)

P-valuec

MDR1 G-rs3789243-A

       

   GG

81

224

0.95

(0.89-1.02)

0.95

(0.89-1.02)

0.01

   GA and AA

278

541

1.03

(0.98-1.08)

1.03

(0.98-1.09)

 

MDR1 C3435T

       

   CC

73

118

1.07

(1.00-1.15)

1.08

(1.00-1.16)

0.02

   CT and TT

286

647

1.00

(0.94-1.05)

1.00

(0.95-1.06)

 

BRCP C421A

       

   CC

296

592

1.02

(0.97-1.07)

1.02

(0.97-1.08)

0.40

   CA and AA

63

173

0.99

(0.91-1.07)

0.99

(0.91-1.08)

 
  1. IRR for colorectal cancer pr intake of additionally 25 g red or processed meat in relation to risk of CRC.
  2. aCrude (adjusted for age and sex).
  3. bAdjusted for status of HRT (women only), smoking status, alcohol, dietary fibre, BMI and NSAID.
  4. cp-value for interaction between genotype and red and processed meat for the fully adjusted estimates.