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Table 3 Incidence rate ratio for colorectal cancer for combinations of MDR1 genotypes

From: Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study

 

IRRa (95% CI) (Ncase/Nsub-cohort)

 

MDR1C3435T

MDR1 G-rs3789243-A

CC

 

CT

 

TT

 

   GG

1.38

(0.31-6.15)

1.16

(0.66-2.06)

1.00b

-

Ncase/Nsub-cohort

(3/6)

 

(27/68)

 

(52/153)

 

   GA

2.20

(1.22-3.96)

1.52

(1.01-2.29)

1.72

(1.06-2.81)

Ncase/Nsub-cohort

(32/42)

 

(110/234)

 

(55/92)

 

   AA

1.80

(1.06-3.05)

1.38

(0.82-2.32)

1.48

(0.58-3.75)

Ncase/Nsub-cohort

(39/72)

 

(38/85)

 

(8/20)

 
  1. a Adjusted for status of HRT, smoking status, alcohol, dietary fibre, red meat and BMI.
  2. bThe most prevalent double homozygous genotype was used as reference.
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BMC Cancer

ISSN: 1471-2407

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