Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study

Table 2 Incidence rate ratio for colorectal cancer for the studied gene polymorphisms.

	N_Case	N_Sub-cohort	IRR^a	(95% CI)	IRR^b	(95% CI)	P-value^c
MDR1 G-rs3789243-A
GG	81	224	1.00	-	1.00	-	0.03
GA	194	365	1.55	(1.13-2.12)	1.55	(1.12-2.14)
AA	84	176	1.43	(0.98-2.08)	1.45	(0.99-2.13)
GA and AA	278	541	1.51	(1.12-2.04)	1.52	(1.12-2.06)
MDR1 C3435T
CC	73	118	1.00	-	1.00	-	0.11
CT	174	385	0.69	(0.49-0.99)	0.74	(0.51-1.07)
TT	112	262	0.66	(0.45-0.96)	0.66	(0.45-0.98)
CT and TT	286	647	0.68	(0.48-0.95)	0.71	(0.50-1.00)
COX-2 G-765C
GG	267	566	1.00	-	1.00	-	0.91
CG	83	186	1.02	(0.75-1.39)	1.03	(0.75-1.41)
CC	9	13	1.45	(0.61-3.48)	1.21	(0.49-2.98)
CG and CC	92	199	1.05	(0.78-1.41)	1.04	(0.77-1.42)
COX-2 A-1195G
AA	230	482	1.00	-	1.00	-	0.88
AG	116	258	0.94	(0.71-1.24)	0.93	(0.70-1.23)
GG	13	25	0.90	(0.44-1.85)	0.94	(0.45-1.95)
AG and GG	129	283	0.93	(0.71-1.22)	0.93	(0.71-1.23)
COX-2 T8473C
TT	147	315	1.00	-	1.00	-	0.37
CT	178	355	1.12	(0.85-1.48)	1.11	(0.83-1.47)
CC	34	95	0.82	(0.52-1.29)	0.81	(0.51-1.28)
CT and CC	212	450	1.06	(0.81-1.38)	1.05	(0.80-1.37)
BRCP C421A
CC	296	592	1.00	-	1.00	-	0.16
CA	58	161	0.72	(0.51-1.01)	0.71	(0.50-1.01)
AA	5	12	1.10	(0.38-3.21)	1.17	(0.39-3.57)
CA and AA	63	173	0.74	(0.53-1.03)	0.73	(0.52-1.04)

^aCrude (adjusted for age and sex).
^bAdjusted for status of HRT (women only), smoking status, alcohol, dietary fibre, red meat, BMI and NSAID.
^cp-value for trend for the fully adjusted estimates.

ISSN: 1471-2407