Skip to main content

Table 1 Genotypes of the Int7G24A polymorphism in cases and controls and their association with CRC.

From: The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: a case-control study

Int7G24A genotype

Cases

(n = 504)

Controls

(n = 504)

OR [95% CI]

p

Dominant model

number (%)

number (%)

  

G/G

296 (58.73)

333 (66.07)

1 (ref)

 

G/A and A/A

208 (41.27)

171 (33.93)

1.37 [1.06-1.77]

0.019*

Additive model

    

G/G

296 (58.73)

333 (66.07)

1 (ref)

 

G/A

178(35.32)

156 (30.95)

1.28 [0.98-1.67]

 

A/A

30 (5.95)

15 (2.98)

2.25 [1.20-4.23]

0.005**

Recessive model

    

G/G and G/A

474 (94.05)

489 (97.02)

1 (ref)

 

A/A

30 (5.95)

15 (2.98)

2.04 [1.11-3.85]

0.032*

 

70 yrs

(n = 213)

70 yrs

(n = 219)

  

G/G, number (%)

118 (55.40)

150 (68.49)

1 (ref)

 

G/A, number (%)

80 (37.56)

61 (27.85)

1.67 [1.11-2.51]

 

A/A, number (%)

15 (7.04)

8 (3.65)

2.38 [1.00-5.68]

0.004**

 

>70 yrs

(n = 227)

>70 yrs

(n = 284)

  

G/G, number (%)

145 (63.88)

182 (64.08)

1 (ref)

 

G/A, number (%)

72 (31.72)

95 (33.45)

0.95 [0.65-1.39]

 

A/A, number (%)

10 (4.41)

7 (2.46)

1.79 [0.69-4.67]

0.662**

 

males

(n = 295)

males

(n = 226)

  

G/G, number (%)

166 (56.27)

160 (70.80)

1 (ref)

 

G/A, number (%)

112 (37.97)

62 (27.43)

1.74 [1.19-2.54]

 

A/A, number (%)

17 (5.76)

4 (1.77)

4.10 [1.41-11.85]

0.00023**

 

females

(n = 202)

females

(n = 277)

  

G/G, number (%)

126 (62.38)

172 (62.09)

1 (ref)

 

G/A, number (%)

63 (31.19)

94 (33.94)

0.92 [0.62-1.36]

 

A/A, number (%)

13 (6.44)

11 (3.97)

1.61 [0.71-3.65]

0.688**

  1. * χ2 test; ** p for trend (Armitage's trend test)