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Table 1 Genotypes of the Int7G24A polymorphism in cases and controls and their association with CRC.

From: The Int7G24A variant of transforming growth factor-beta receptor type I is a risk factor for colorectal cancer in the male Spanish population: a case-control study

Int7G24A genotype Cases
(n = 504)
Controls
(n = 504)
OR [95% CI] p
Dominant model number (%) number (%)   
G/G 296 (58.73) 333 (66.07) 1 (ref)  
G/A and A/A 208 (41.27) 171 (33.93) 1.37 [1.06-1.77] 0.019*
Additive model     
G/G 296 (58.73) 333 (66.07) 1 (ref)  
G/A 178(35.32) 156 (30.95) 1.28 [0.98-1.67]  
A/A 30 (5.95) 15 (2.98) 2.25 [1.20-4.23] 0.005**
Recessive model     
G/G and G/A 474 (94.05) 489 (97.02) 1 (ref)  
A/A 30 (5.95) 15 (2.98) 2.04 [1.11-3.85] 0.032*
 70 yrs
(n = 213)
70 yrs
(n = 219)
  
G/G, number (%) 118 (55.40) 150 (68.49) 1 (ref)  
G/A, number (%) 80 (37.56) 61 (27.85) 1.67 [1.11-2.51]  
A/A, number (%) 15 (7.04) 8 (3.65) 2.38 [1.00-5.68] 0.004**
  >70 yrs
(n = 227)
>70 yrs
(n = 284)
  
G/G, number (%) 145 (63.88) 182 (64.08) 1 (ref)  
G/A, number (%) 72 (31.72) 95 (33.45) 0.95 [0.65-1.39]  
A/A, number (%) 10 (4.41) 7 (2.46) 1.79 [0.69-4.67] 0.662**
  males
(n = 295)
males
(n = 226)
  
G/G, number (%) 166 (56.27) 160 (70.80) 1 (ref)  
G/A, number (%) 112 (37.97) 62 (27.43) 1.74 [1.19-2.54]  
A/A, number (%) 17 (5.76) 4 (1.77) 4.10 [1.41-11.85] 0.00023**
  females
(n = 202)
females
(n = 277)
  
G/G, number (%) 126 (62.38) 172 (62.09) 1 (ref)  
G/A, number (%) 63 (31.19) 94 (33.94) 0.92 [0.62-1.36]  
A/A, number (%) 13 (6.44) 11 (3.97) 1.61 [0.71-3.65] 0.688**
  1. * χ2 test; ** p for trend (Armitage's trend test)