Differentially expressed miRNA between normal colon and tumor tissue. Heatmaps of significantly differentially expressed miRNAs. All miRNA expression data is shown relative to the average value of normal colon. Both tissue median and average fold-change values between the two comparison groups are shown. miRNAs found in close proximity within the genome that also show correlation with each other are highlighted in gray. P-values < 10e-16 represented as 0. (A) Normal colon samples compared to tumors. (B) dMMR colon cancers are compared to pMMR colon tumors. (C) Unsupervised hierarchical clustering of tumors using 43 miRNA found to be significant. Samples improperly defined by SVM cross-validation denoted with asterisk.