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Table 5 Joint effects of AFB1-exposure years and XPD codon 751 polymorphism on HCC risk

From: XPD codon 312 and 751 polymorphisms, and AFB1 exposure, and hepatocellular carcinoma risk

  

Controls

HCCs

  

AFB1-exposure yearsa, b

XPD genotypes

n

%

n

%

OR (95% CI)

Adjusted OR (95% CI)c

Short

LL

255

35.8

66

10.7

Reference

Reference

 

LG

97

13.6

40

6.5

1.59(1.01-2.52)

1.30(0.77-2.20)

 

GG

26

3.7

24

3.9

3.57(1.92-6.61)

3.70(1.80-7.59)

Medium

LL

124

17.4

78

12.6

2.43(1.64-3.60)

8.77(5.29-14.53)

 

LG

47

6.6

70

11.3

5.75(3.64-9.10)

14.38 (7.26-28.48)

 

GG

26

3.7

48

7.8

7.13(4.12-12.35)

18.52 (10.24-33.50)

Long

LL

85

11.9

128

20.7

5.82(3.96-8.55)

149.12(70.43-315.72)

 

LG

43

6.0

112

18.1

10.06(6.46-15.68)

290.55(125.56-672.36)

 

GG

9

1.3

52

8.4

22.32(10.47-47.62)

470.25(163.21-1354.96)

  1. a From the likelihood ratio test comparing the fit of the logistic model that included the main effects of AFB1-exposure years, genotypes and all potential confounders with a fully parameterized model containing the interaction terms of XPD codon 751 genotypes and AFB1-exposure years (interact term OR = 0.85, P interaction = 0.011).
  2. b AFB1-exposure years were: < 40 years for short exposure; 40 - 48 years for medium exposure; > 48 years for long exposure.
  3. c Adjusted for age, sex, ethnicity, HBsAg, anti-HCV, and AFB1-DNA adducts levels.
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BMC Cancer

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