Skip to main content

Table 4 XPD codon 751 polymorphism and HCC risk stratified by HBV infection (HBsAg- negative and positive), HCV infection (anti-HCV- negative and positive), and gender (female and male)

From: XPD codon 312 and 751 polymorphisms, and AFB1 exposure, and hepatocellular carcinoma risk

  

Controls

HCCs

  
  

n

%

n

%

OR (95% CI)

Adjusted OR (95% CI)

HBsAga

XPD

      

   Negative

LL

153

75.0

86

51.2

Reference

Reference

 

LG

32

15.7

56

33.3

3.11(1.87-5.18)

2.36(1.25-4.45)b

 

GG

19

9.3

26

15.5

2.44(1.27-4.46)

1.42(0.60-3.36)b

 

LG/GG

51

25.0

82

48.8

2.86(1.85-4.43)

2.01(1.16-3.51)b

   Positive

LL

311

61.2

186

41.3

Reference

Reference

 

LG

155

30.5

166

36.9

1.79(1.35-2.38)

1.52(1.08-2.16)b

 

GG

42

8.3

98

21.8

3.90(2.60-5.85)

2.64(1.60-4.37)b

 

LG/GG

197

38.8

264

58.7

2.24(1.73-2.90)

1.77(1.29-2.43)b

Anti-HCVc

XPD

      

   Negative

LL

387

66.3

223

44.2

Reference

Reference

 

LG

150

25.7

185

36.7

2.14(1.63-2.81)

1.93(1.39-2.70)d

 

GG

47

8.0

96

19.0

3.55(2.41-5.21)

2.93(1.82-4.72)d

 

LG/GG

197

33.7

281

55.8

2.48(1.94-3.17)

2.17(1.60-2.94)d

   Positive

LL

77

60.2

49

43.0

Reference

Reference

 

LG

37

28.9

37

32.5

1.57(0.88-2.81)

1.28(0.70-2.34)d

 

GG

14

10.9

28

24.6

3.14(1.51-6.55)

2.77(1.29-5.93)d

 

LG/GG

51

39.8

65

57.0

2.00(1.20-3.34)

1.68(0.99-2.85)d

   Sexe

XPD

      

   Female

LL

133

77.3

65

38.2

Reference

Reference

 

LG

33

19.2

81

47.6

5.02(3.04-8.30)

5.64(3.33-9.56)f

 

GG

6

3.5

24

14.1

8.19(3.19-21.01)

8.58(3.28-22.46)f

 

LG/GG

39

22.7

105

61.8

5.51(3.44-8.83)

6.12(3.72-10.05)f

   Male

LL

331

61.3

207

46.2

Reference

Reference

 

LG

154

28.5

141

31.5

1.46(1.10-1.95)

1.50(1.12-2.01)f

 

GG

55

10.2

100

22.3

2.91(2.00-4.22)

2.90(1.99-4.21)f

 

LG/GG

209

38.7

241

53.8

1.84(1.43-2.38)

1.88(1.45-2.43)f

  1. aLikelihood ration test for interaction of the stratified variable (HBsAg-negative and positive) and XPD codon 751 genotype was calculated as test for the heterogeneity of ORs across strata (interact term OR = 1.02, P interaction = 0.938).
  2. bAdjusted for age, sex, ethnicity, anti-HCV, AFB1-exposure years, and AFB1-DNA adduct levels.
  3. cLikelihood ration test for interaction of the stratified variable (anti-HCV-negative and positive) and XPD codon 751 genotype was calculated as test for the heterogeneity of ORs across strata (interact term OR = 0.87, P interaction = 0.492).
  4. dAdjusted for age, sex, ethnicity, HBsAg, AFB1-exposure years, and AFB1-DNA adduct levels.
  5. eLikelihood ration test for interaction of the stratified variable (female and male) and XPD codon 751 genotype was calculated as test for the heterogeneity of ORs across strata (interact term OR = 0.43, P interaction = 0.0001).
  6. fAdjusted for age, ethnicity, HBsAg, anti-HCV, AFB1-exposure years, and AFB1-DNA adduct levels.