Figure 6

Cleavage of PARP was detected using western blot assay. Significant increase in apoptosis was observed for drug sensitive (A) and multidrug resistant osteosarcoma cells (B) when they were treated with doxorubicin loaded nanoparticle. Bar graphs represent the result of semiquantification by reverse image scanning densitometry with PhotoShop 7.0 (C, D). P values are shown as follows: *P < 0.05.